Diabetic nephropathy (DN) is a widely recognized microvascular complication of diabetes and almost the leading cause of end-stage kidney failure worldwide responsible for morbidity and mortality [1]. If the damage to the kidney and proteinuria is irreversible, it will evolve into End-Stage Renal Disease. However, exact pathogenesis of DN is still unclear and it is difficult for us to cure DN. At present diet management, control of blood pressure and blood sugar, and blood fat treatment are the foundation treatment for DN. Furthermore, an adequate control of high blood pressure and treatment of microalbuminuria are the major therapeutic targets [2]. To achieve adequate blood pressure control, a combination therapy with different classes of antihypertensive agents is often necessary, especially including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) [3]. ACEIs and ARBs have been demonstrated to protect renal function of DN but are not enough to delay or retard the progression of DN; therefore, exploring feasible drugs is the hotspot of medical research at present.
Human's hand bones. It's named in Japanese. Reprint from Gray's Anatomy, and edited by T-310. Image sourced from Wikimedia Commons. Available here.