These formulas were applied for delirium, coma, and convulsions-conditions that were thought (by many) to occur because demons penetrated the body. Using the more commonly relied upon descriptions of the medicinal materials and their actions, these substances opened blocked orifices (e.g., borneol, musk, benzoin, and ox gallstone), calmed agitation (succinum, cinnabar, pearl), and removed heat toxin (coptis, scute, gardenia). However, one can see by the selection of the particular materials, that these were "precious pills" relied upon for the disorders that were beyond the usual experience.