A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women

Antidepressant-induced sexual dysfunction (AISD) is a significant complication in the treatment of patients with mood and anxiety disorders, affecting more than half of patients who are taking selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) [1], and has been associated with reduced quality of life, reduced self-esteem, and negative effects on mood and relationships [1]. Sexual dysfunction may affect any phase of the sexual response cycle including libido, arousal, and/or orgasm [2]. Because adequate sexual function is an integral aspect of quality of life, many patients whose depression is in remission as a result of taking antidepressant medication may elect to switch or discontinue their treatment, increasing their risk of complications from their underlying psychiatric disorder [3]. AISD is a major reason for medication discontinuation [4].