Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells

Chaga mushroom (Inonotus obliquus), a white rot fungus, belongs to the hymenochaetaceae family of Basidomycetes. Chaga mushroom grows on birch trees in colder northern climates[1]. Since the sixteenth century, Chaga has been used as a folk medicine in Russia and western Siberia[2]. Recently, many polyphenolic compounds including triterpenoids, steroids, and ergosterol peroxides from Inonotus sclerotia have shown various biological activities, including anti-bacterial[3], hepato-protective[4], and anti-tumor[5–7] effects. However, its molecular mechanisms to the anti-tumor effects have not been well documented, in spite of its increasing usage.